The CLC Genomics Workbench is a comprehensive package that analyzes and visualizes data from all major next-generation HTS platforms, such as SOLiD by Applied Biosystems, 454 GSflx by Roche, and Solexa by Illumina. “So there’s a critical demand for solutions that are really adept at handling and analyzing these huge amounts of data,” he says. In fact, the amount of genomic sequencing data increases 10-fold every 18 months. Whereas first-generation sequencing machines typically generate 0.1 megabases of data per run, second-generation instruments can spew out up to 40,000 megabases in a single run, explains Knudsen. The CLC Genomics Workbench, released in 2008, analyzes data from second-generation HTS instruments. In 2007, the company switched its focus to the analysis of next-generation sequencing data. Right: comparing expression across samples and clustering differentially expressed genes in a heat map Working with RNA-Seq data in CLC Genomics Workbench: Left: mapping of reads showing evidence of expression of three splice variants for this gene. Although designed for first-generation sequence data, he believes that the software makes a good teaching tool for students in molecular biology.
CLC GENOMICS WORKBENCH ILLUMINA HOW TO
When first launched, the software was “a powerful and intuitive way to show people how to do bioinformatics,” says Thomas Knudsen. In the first year, 100,000 downloads occurred, and by 2008, the number of downloads passed one million. The Sequence Viewer software remains free and can be downloaded from the company’s website.
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